SC Connecticut News

Combining genomic analyses with information about clinical outcomes is a promising strategy for understanding prostate cancer and its treatment. Researchers suggest it could change how the disease is predicted and make treatment more timely and personalized.

Yale Urology Associate Professors Michael S. Leapman, MD, MHS, and Preston C. Sprenkle, MD, led the research efforts published on June 14 in JAMA Network Open. In a large collaborative study, described as the most extensive clinical-transcriptomic linkage ever accomplished, more than 92,000 patients were reviewed. Each had undergone genomic classifier testing between 2016 and 2022 with the Decipher Classifier, a commercially available tool used to estimate prostate cancer risk. They were then linked with administrative information, including insurance claims, pharmacy records, and electronic health record (EHR) data.

“Alignment of this data [both clinical and genomic],” says Leapman, “is especially important as it provides a platform for understanding how observed cancer genomic signatures relate to short- and long-term patient outcomes. This information, and future expansions of this work,” adds Leapman, “could help refine the ways in which key clinical decisions are made – such as which prostate cancers should be treated, and with what approach.”

The study leverages transcriptomic profiling using the Decipher Classifier. Leapman says it contains “over 1.4 million features including 46,000 coding and non-coding genes.”

According to the paper, the study’s authors “validate[d] and refine[d] algorithms that identif[ied] key prostate cancer events,” such as dates of diagnosis, rising PSA levels, and metastasis.

“One of the exciting opportunities with large scale research like this,” says Sprenkle, “is the potential to evaluate the impact of testing and interventions on men with lower risk prostate cancer to better understand who can avoid intervention. This is something typically difficult to assess in small single-institution studies or even clinical trials.”

Other Yale authors on the study include Darryl Martin, PhD, and Yi An, MD.